VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

Concerted co-regulation of multiple signalling pathways is crucial for tissue homoeostasis and tumorigenesis. Here we report that VGLL4, a previously identified YAP antagonist, also functions as a regulator of Wnt/β-catenin signalling. The expression of VGLL4 is significantly downregulated in clinic...

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Detalles Bibliográficos
Autores principales: Jiao, Shi, Li, Chuanchuan, Hao, Qian, Miao, Haofei, Zhang, Lei, Li, Lin, Zhou, Zhaocai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216127/
https://www.ncbi.nlm.nih.gov/pubmed/28051067
http://dx.doi.org/10.1038/ncomms14058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216127/
https://www.ncbi.nlm.nih.gov/pubmed/28051067
http://dx.doi.org/10.1038/ncomms14058

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