Cargando…

Meprin β contributes to collagen deposition in lung fibrosis

Lung fibrosis is a severe disease characterized by epithelial cell injury, inflammation and collagen deposition. The metalloproteases meprinα and meprinβ have been shown to enhance collagen maturation and inflammatory cell infiltration via cleavage of cell-cell contact molecules; therefore we hypoth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Biasin, V., Wygrecka, M., Marsh, L. M., Becker-Pauly, C., Brcic, L., Ghanim, B., Klepetko, W., Olschewski, A., Kwapiszewska, G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216360/ https://www.ncbi.nlm.nih.gov/pubmed/28059112 http://dx.doi.org/10.1038/srep39969

Ejemplares similares

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis
por: Broder, Claudia, et al.
Publicado: (2013)

Distinct contributions of meprins to skin regeneration after injury – Meprin α a physiological processer of pro-collagen VII
por: Kruppa, Daniel, et al.
Publicado: (2021)

CDK4/6 inhibition enhances pulmonary inflammatory infiltration in bleomycin-induced lung fibrosis
por: Birnhuber, Anna, et al.
Publicado: (2020)

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP
por: Becker-Pauly, Christoph, et al.
Publicado: (2017)

The putative pleiotropic functions of meprin β in gastric cancer
por: Siemsen, Wiebke, et al.
Publicado: (2023)

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10
por: Jefferson, Tamara, et al.
Publicado: (2012)

The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension
por: Marsh, Leigh M., et al.
Publicado: (2018)

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP
por: Sammel, Martin, et al.
Publicado: (2019)

IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis
por: Birnhuber, Anna, et al.
Publicado: (2019)

PDGFRα and αSMA mark two distinct mesenchymal cell populations involved in parenchymal and vascular remodeling in pulmonary fibrosis
por: Biasin, Valentina, et al.
Publicado: (2020)

Metalloprotease Meprinβ in Rat Kidney: Glomerular Localization and Differential Expression in Glomerulonephritis
por: Oneda, Beatrice, et al.
Publicado: (2008)

Evaluation of (¹¹¹)In-Labelled Exendin-4 Derivatives Containing Different Meprin β-Specific Cleavable Linkers
por: Jodal, Andreas, et al.
Publicado: (2015)

Pirfenidone exacerbates Th2-driven vasculopathy in a mouse model of systemic sclerosis-associated interstitial lung disease
por: Birnhuber, Anna, et al.
Publicado: (2022)

High-mobility group box-1 induces vascular remodelling processes via c-Jun activation
por: Zabini, Diana, et al.
Publicado: (2015)

Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold‐Hopping Approach
por: Tan, Kathrin, et al.
Publicado: (2020)

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)
por: Hou, Shurong, et al.
Publicado: (2021)

RGS5 Determines Neutrophil Migration in the Acute Inflammatory Phase of Bleomycin-Induced Lung Injury
por: Sharma, Neha, et al.
Publicado: (2021)

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)
por: Wang, Chao, et al.
Publicado: (2021)

New links for meprin β within the protease web
por: Canbay, Vahap, et al.
Publicado: (2022)

Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R
por: Gellrich, Antonin, et al.
Publicado: (2021)

Fra2 Overexpression in Mice Leads to Non-allergic Asthma Development in an IL-13 Dependent Manner
por: Gungl, Anna, et al.
Publicado: (2018)

Origin and Diversification of Meprin Proteases
por: Marín, Ignacio
Publicado: (2015)

Resident cell lineages are preserved in pulmonary vascular remodeling
por: Crnkovic, Slaven, et al.
Publicado: (2018)

Cell Surface Processing of CD109 by Meprin β Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles
por: Lückstädt, Wiebke, et al.
Publicado: (2021)

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site
por: Schönherr, Caroline, et al.
Publicado: (2016)

Dysbalance of ACE2 levels – a possible cause for severe COVID‐19 outcome in COPD
por: Fließer, Elisabeth, et al.
Publicado: (2021)

Machine Learning Analysis of the Bleomycin Mouse Model Reveals the Compartmental and Temporal Inflammatory Pulmonary Fingerprint
por: Bordag, Natalie, et al.
Publicado: (2020)

The Metalloprotease Meprinβ Processes E-Cadherin and Weakens Intercellular Adhesion
por: Huguenin, Maya, et al.
Publicado: (2008)

Hypoxia Associated Proteolytic Processing of OS-9 by the Metalloproteinase Meprin β
por: Martin, Barry Lee, et al.
Publicado: (2016)

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor
por: Linnert, Miriam, et al.
Publicado: (2021)

Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases
por: Karmilin, Konstantin, et al.
Publicado: (2019)

Let It Flow: Morpholino Knockdown in Zebrafish Embryos Reveals a Pro-Angiogenic Effect of the Metalloprotease Meprin α(2)
por: Schütte, André, et al.
Publicado: (2010)

Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease
por: Marengo, Liana, et al.
Publicado: (2022)

Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
por: Bülck, Cynthia, et al.
Publicado: (2023)

Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β
por: Tan, Kathrin, et al.
Publicado: (2023)

Role of Meprins to Protect Ileal Mucosa of Crohn's Disease Patients from Colonization by Adherent-Invasive E. coli
por: Vazeille, Emilie, et al.
Publicado: (2011)

Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin
por: Breig, Osman, et al.
Publicado: (2016)

Enhanced Activity of Meprin-α, a Pro-Migratory and Pro-Angiogenic Protease, in Colorectal Cancer
por: Lottaz, Daniel, et al.
Publicado: (2011)

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling
por: Arnold, Philipp, et al.
Publicado: (2017)

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro
por: Bedau, Tillmann, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_c1nlqv06t42lht7bjs0v13euvo