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Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner
Nephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation of BER produces toxic repair intermediates that damage healthy tissues. We have...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216697/ https://www.ncbi.nlm.nih.gov/pubmed/27391435 http://dx.doi.org/10.18632/oncotarget.10440 |