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Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner

Nephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation of BER produces toxic repair intermediates that damage healthy tissues. We have...

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Detalles Bibliográficos
Autores principales:	Calvo, Jennifer A., Allocca, Mariacarmela, Fake, Kimberly R., Muthupalani, Sureshkumar, Corrigan, Joshua J., Bronson, Roderick T., Samson, Leona D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216697/ https://www.ncbi.nlm.nih.gov/pubmed/27391435 http://dx.doi.org/10.18632/oncotarget.10440

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