MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma

Neddylation is a post-translational protein modification process associated with carcinogenesis and cancer development. MLN4924, a pharmaceutical neddylation inhibitor, induces potent anti-cancer effects in multiple types of cancers. In this study, we investigated the effects of MLN4924 on human ost...

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Detalles Bibliográficos
Autores principales: Zhang, Yi, Shi, Cheng-Cheng, Zhang, Hua-Peng, Li, Gong-Quan, Li, Shan-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216721/
https://www.ncbi.nlm.nih.gov/pubmed/27223074
http://dx.doi.org/10.18632/oncotarget.9481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216721/
https://www.ncbi.nlm.nih.gov/pubmed/27223074
http://dx.doi.org/10.18632/oncotarget.9481

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