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MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma

Neddylation is a post-translational protein modification process associated with carcinogenesis and cancer development. MLN4924, a pharmaceutical neddylation inhibitor, induces potent anti-cancer effects in multiple types of cancers. In this study, we investigated the effects of MLN4924 on human ost...

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Detalles Bibliográficos
Autores principales:	Zhang, Yi, Shi, Cheng-Cheng, Zhang, Hua-Peng, Li, Gong-Quan, Li, Shan-Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216721/ https://www.ncbi.nlm.nih.gov/pubmed/27223074 http://dx.doi.org/10.18632/oncotarget.9481

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