The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells

Relapse after treatment is a common and unresolved problem for patients suffering of the B-cell chronic lymphocytic leukemia (B-CLL). Here we investigated the ability of the isopeptidase inhibitor 2cPE to trigger apoptosis in leukemia cells in comparison with bortezomib, another inhibitor of the ubi...

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Detalles Bibliográficos
Autores principales: Tomasella, Andrea, Picco, Raffaella, Ciotti, Sonia, Sgorbissa, Andrea, Bianchi, Elisa, Manfredini, Rossella, Benedetti, Fabio, Trimarco, Valentina, Frezzato, Federica, Trentin, Livio, Semenzato, Gianpietro, Delia, Domenico, Brancolini, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216732/
https://www.ncbi.nlm.nih.gov/pubmed/27259251
http://dx.doi.org/10.18632/oncotarget.9742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216732/
https://www.ncbi.nlm.nih.gov/pubmed/27259251
http://dx.doi.org/10.18632/oncotarget.9742

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