C-met inhibition blocks bone metastasis development induced by renal cancer stem cells

Cancer stem cells (CSCs) are key players in bone metastasis. In some renal tumors CSCs overexpress the HGF receptor c-MET, speculating that c-MET targeting could lead to bone metastasis inhibition. To address this hypothesis we isolated renal CD105+/CD24−CSCs, expressing c-MET receptor from a primar...

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Detalles Bibliográficos
Autores principales: D'Amico, Lucia, Belisario, Dimas, Migliardi, Giorgia, Grange, Cristina, Bussolati, Benedetta, D'Amelio, Patrizia, Perera, Timothy, Dalmasso, Ettore, Carbonare, Luca Dalle, Godio, Laura, Comoglio, Paolo, Trusolino, Livio, Ferracini, Riccardo, Roato, Ilaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216739/
https://www.ncbi.nlm.nih.gov/pubmed/27322553
http://dx.doi.org/10.18632/oncotarget.9997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216739/
https://www.ncbi.nlm.nih.gov/pubmed/27322553
http://dx.doi.org/10.18632/oncotarget.9997

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