Cargando…

C-met inhibition blocks bone metastasis development induced by renal cancer stem cells

Cancer stem cells (CSCs) are key players in bone metastasis. In some renal tumors CSCs overexpress the HGF receptor c-MET, speculating that c-MET targeting could lead to bone metastasis inhibition. To address this hypothesis we isolated renal CD105+/CD24−CSCs, expressing c-MET receptor from a primar...

Descripción completa

Detalles Bibliográficos
Autores principales:	D'Amico, Lucia, Belisario, Dimas, Migliardi, Giorgia, Grange, Cristina, Bussolati, Benedetta, D'Amelio, Patrizia, Perera, Timothy, Dalmasso, Ettore, Carbonare, Luca Dalle, Godio, Laura, Comoglio, Paolo, Trusolino, Livio, Ferracini, Riccardo, Roato, Ilaria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216739/ https://www.ncbi.nlm.nih.gov/pubmed/27322553 http://dx.doi.org/10.18632/oncotarget.9997

Ejemplares similares

Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature
por: D′Amico, L, et al.
Publicado: (2013)

The Met oncogene and basal-like breast cancer: another culprit to watch out for?
por: Gastaldi, Stefania, et al.
Publicado: (2010)

ROR1 is a pseudokinase that is crucial for MET-driven tumorigenesis
por: Lazzari, Luca, et al.
Publicado: (2013)

Bone invading NSCLC cells produce IL-7: mice model and human histologic data
por: Roato, Ilaria, et al.
Publicado: (2010)

Iloprost modulates the immune response in systemic sclerosis
por: D'Amelio, Patrizia, et al.
Publicado: (2010)

DKK-1 in prostate cancer diagnosis and follow up
por: D’Amelio, Patrizia, et al.
Publicado: (2014)

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition
por: Corso, Simona, et al.
Publicado: (2010)

Adipose Derived-Mesenchymal Stem Cells Viability and Differentiating Features for Orthopaedic Reparative Applications: Banking of Adipose Tissue
por: Roato, Ilaria, et al.
Publicado: (2016)

Discovery of molecular determinants of response to targeted therapies in colorectal cancer using patient-derived xenografts (‘xenopatients’)
por: Sassi, Francesco, et al.
Publicado: (2013)

An mTOR feedback loop mediates the ‘flare’ (‘rebound’) response to MET tyrosine kinase inhibition
por: Altintas, D. M., et al.
Publicado: (2023)

Osteoclasts Are Active in Bone Forming Metastases of Prostate Cancer Patients
por: Roato, Ilaria, et al.
Publicado: (2008)

β4 integrin activates a Shp2–Src signaling pathway that sustains HGF-induced anchorage-independent growth
por: Bertotti, Andrea, et al.
Publicado: (2006)

Adipose-Derived Stromal Vascular Fraction/Xenohybrid Bone Scaffold: An Alternative Source for Bone Regeneration
por: Roato, Ilaria, et al.
Publicado: (2018)

CD73/Adenosine Pathway Involvement in the Interaction of Non-Small Cell Lung Cancer Stem Cells and Bone Cells in the Pre-Metastatic Niche
por: Bertolini, Giulia, et al.
Publicado: (2022)

Bone Impairment in Phenylketonuria Is Characterized by Circulating Osteoclast Precursors and Activated T Cell Increase
por: Roato, Ilaria, et al.
Publicado: (2010)

The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors
por: D'Amico, Lucia, et al.
Publicado: (2015)

Cancer Stem Cells, Bone and Tumor Microenvironment: Key Players in Bone Metastases
por: Roato, Ilaria, et al.
Publicado: (2018)

Ex vivo manipulation of bone marrow cells to rescue uremia-induced dysfunction for autologous therapy
por: Grange, Cristina, et al.
Publicado: (2015)

Extracellular vesicles in kidney disease
por: Grange, Cristina, et al.
Publicado: (2022)

Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue
por: Ferracini, R., et al.
Publicado: (2022)

CXCR4 Inhibition Counteracts Immunosuppressive Properties of Metastatic NSCLC Stem Cells
por: Fortunato, Orazio, et al.
Publicado: (2020)

A Mouse Model of Pulmonary Metastasis from Spontaneous Osteosarcoma Monitored In Vivo by Luciferase Imaging
por: Miretti, Silvia, et al.
Publicado: (2008)

Extracellular Vesicles and Carried miRNAs in the Progression of Renal Cell Carcinoma
por: Grange, Cristina, et al.
Publicado: (2019)

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours
por: Martin, Valentina, et al.
Publicado: (2019)

Endothelial cell differentiation of human breast tumour stem/progenitor cells
por: Bussolati, Benedetta, et al.
Publicado: (2009)

Potential Applications of Extracellular Vesicles in Solid Organ Transplantation
por: Grange, Cristina, et al.
Publicado: (2020)

Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration
por: Grange, Cristina, et al.
Publicado: (2019)

Announcement: A new open access journal from AIP Publishing and the American Crystallographic Association—Structural Dynamics
por: D'Amelio, Bridget
Publicado: (2014)

Vitamin D Deficiency and Risk of Metabolic Syndrome in Aging Men
por: D'Amelio, Patrizia
Publicado: (2021)

Editorial for Special Issue: Microbial and Autoimmune Disease
por: D’Amelio, Raffaele
Publicado: (2021)

An Observatory for the MET Oncogene: A Guide for Targeted Therapies
por: Altintas, Dogus M., et al.
Publicado: (2023)

MET Oncogene Controls Invasive Growth by Coupling with NMDA Receptor
por: Gallo, Simona, et al.
Publicado: (2022)

Human CD133(+) Renal Progenitor Cells Induce Erythropoietin Production and Limit Fibrosis After Acute Tubular Injury
por: Aggarwal, Shikhar, et al.
Publicado: (2016)

Hypovitaminosis D and Aging: Is There a Role in Muscle and Brain Health?
por: D’Amelio, Patrizia, et al.
Publicado: (2020)

Gazing at Social Interactions Between Foraging and Decision Theory
por: D'Amelio, Alessandro, et al.
Publicado: (2021)

Can the military contribute to global surveillance and control of infectious diseases?
por: D'Amelio, R, et al.
Publicado: (1998)

Osteogenic Differentiation Modulates the Cytokine, Chemokine, and Growth Factor Profile of ASCs and SHED
por: Mussano, Federico, et al.
Publicado: (2018)

Male Osteoporosis in the Elderly
por: D'Amelio, Patrizia, et al.
Publicado: (2015)

Corrigendum to “Male Osteoporosis in the Elderly”
por: D'Amelio, Patrizia, et al.
Publicado: (2017)

Molecular Basis of the Anticancer and Antibacterial Properties of CecropinXJ Peptide: An In Silico Study
por: Ramos-Martín, Francisco, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mpmbhp5gp9dgpkv103t0u2mb94