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KLF4α stimulates breast cancer cell proliferation by acting as a KLF4 antagonist

Krüppel-like factor 4 (KLF4), a transcription factor involved in both tumor suppression and oncogenesis in various human tumors, is subject to alternative splicing that produces KLF4α. KLF4α is primarily expressed in the cytoplasm because it lacks exon 3 of KLF4, which contains the nuclear localizat...

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Detalles Bibliográficos
Autores principales: Ferralli, Jacqueline, Chiquet-Ehrismann, Ruth, Degen, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216746/
https://www.ncbi.nlm.nih.gov/pubmed/27323810
http://dx.doi.org/10.18632/oncotarget.10058