Extremely stringent activation of p16(INK4a) prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression

Cervical epithelial cell immortalization with defined genetic factors without viral oncogenes has never been reported. Here we report that HPV-negative cervical epithelial cells failed to be immortalized by telomerase activation or the combination of p53 knockdown and telomerase activation. Under th...

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Detalles Bibliográficos
Autores principales: Hang, Su, Tiwari, Agnes F.Y., Ngan, Hextan Y.S., Yip, Yim-Ling, Cheung, Annie L.M., Tsao, Sai Wah, Deng, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216750/
https://www.ncbi.nlm.nih.gov/pubmed/27344169
http://dx.doi.org/10.18632/oncotarget.10120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216750/
https://www.ncbi.nlm.nih.gov/pubmed/27344169
http://dx.doi.org/10.18632/oncotarget.10120

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