Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway

Nicotinamide N-methyltransferase (NNMT), which converts nicotinamide to 1-methylnicotinamide (1-MNA), is overexpressed in a variety of human cancers and serves as a potential anti-cancer target. In this study, we investigated the effect of NNMT on 5-fluorouracil (5-FU) sensitivity of colorectal canc...

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Detalles Bibliográficos
Autores principales: Xie, Xinyou, Liu, Huixing, Wang, Yanzhong, Zhou, Yanwen, Yu, Haitao, Li, Guiling, Ruan, Zhi, Li, Fengying, Wang, Xiuhong, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216764/
https://www.ncbi.nlm.nih.gov/pubmed/27323852
http://dx.doi.org/10.18632/oncotarget.9962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216764/
https://www.ncbi.nlm.nih.gov/pubmed/27323852
http://dx.doi.org/10.18632/oncotarget.9962

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