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Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway

Nicotinamide N-methyltransferase (NNMT), which converts nicotinamide to 1-methylnicotinamide (1-MNA), is overexpressed in a variety of human cancers and serves as a potential anti-cancer target. In this study, we investigated the effect of NNMT on 5-fluorouracil (5-FU) sensitivity of colorectal canc...

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Detalles Bibliográficos
Autores principales:	Xie, Xinyou, Liu, Huixing, Wang, Yanzhong, Zhou, Yanwen, Yu, Haitao, Li, Guiling, Ruan, Zhi, Li, Fengying, Wang, Xiuhong, Zhang, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216764/ https://www.ncbi.nlm.nih.gov/pubmed/27323852 http://dx.doi.org/10.18632/oncotarget.9962

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