NF-Y loss triggers p53 stabilization and apoptosis in HPV18-positive cells by affecting E6 transcription

The expression of the high risk HPV18 E6 and E7 oncogenic proteins induces the transformation of epithelial cells, through the disruption of p53 and Rb function. The binding of cellular transcription factors to cis-regulatory elements in the viral Upstream Regulatory Region (URR) stimulates E6/E7 tr...

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Detalles Bibliográficos
Autores principales: Benatti, Paolo, Basile, Valentina, Dolfini, Diletta, Belluti, Silvia, Tomei, Margherita, Imbriano, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216769/
https://www.ncbi.nlm.nih.gov/pubmed/27323853
http://dx.doi.org/10.18632/oncotarget.9974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216769/
https://www.ncbi.nlm.nih.gov/pubmed/27323853
http://dx.doi.org/10.18632/oncotarget.9974

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