Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

BACKGROUND: Glioblastomas (GBM) present a high cellular heterogeneity with conspicuous necrotic regions associated with hypoxia, which is related to tumor aggressiveness. GBM tumors exhibit high glycolytic metabolism with increased lactate production that is extruded to the tumor microenvironment th...

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Detalles Bibliográficos
Autores principales: Miranda-Gonçalves, Vera, Granja, Sara, Martinho, Olga, Honavar, Mrinalini, Pojo, Marta, Costa, Bruno M., Pires, Manuel M., Pinheiro, Célia, Cordeiro, Michelle, Bebiano, Gil, Costa, Paulo, Reis, Rui M., Baltazar, Fátima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216802/
https://www.ncbi.nlm.nih.gov/pubmed/27331625
http://dx.doi.org/10.18632/oncotarget.10114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216802/
https://www.ncbi.nlm.nih.gov/pubmed/27331625
http://dx.doi.org/10.18632/oncotarget.10114

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