Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells

Leukemia cells are highly dependent on glucose and glutamine as bioenergetic and biosynthetic fuels. Inhibition of the metabolism of glucose but also of glutamine is thus proposed as a therapeutic modality to block leukemia cell growth. Since glucose also supports protein glycosylation, we wondered...

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Detalles Bibliográficos
Autores principales: Polet, Florence, Martherus, Ruben, Corbet, Cyril, Pinto, Adan, Feron, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216804/
https://www.ncbi.nlm.nih.gov/pubmed/27344174
http://dx.doi.org/10.18632/oncotarget.10131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216804/
https://www.ncbi.nlm.nih.gov/pubmed/27344174
http://dx.doi.org/10.18632/oncotarget.10131

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