CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter

DNA hypermethylation at the promoter of tumour-suppressor genes is tightly correlated with their transcriptional repression and recognized as the hallmark of majority of cancers. Epigenetic silencing of tumour suppressor genes impairs their cellular functions and activates a cascade of events drivin...

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Detalles Bibliográficos
Autores principales: Choudhury, Samrat Roy, Cui, Yi, Lubecka, Katarzyna, Stefanska, Barbara, Irudayaraj, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216816/
https://www.ncbi.nlm.nih.gov/pubmed/27356740
http://dx.doi.org/10.18632/oncotarget.10234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216816/
https://www.ncbi.nlm.nih.gov/pubmed/27356740
http://dx.doi.org/10.18632/oncotarget.10234

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