The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus

Humanin is a small secreted peptide that is encoded in the mitochondrial genome. Humanin and its analogues have a protective role in multiple age-related diseases including type 2 diabetes and Alzheimer's disease, through cytoprotective and neuroprotective effects both in vitro and in vivo. How...

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Detalles Bibliográficos
Autores principales: Kim, Su-Jeong, Guerrero, Noel, Wassef, Gabriella, Xiao, Jialin, Mehta, Hemal H., Cohen, Pinchas, Yen, Kelvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216912/
https://www.ncbi.nlm.nih.gov/pubmed/27384491
http://dx.doi.org/10.18632/oncotarget.10380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216912/
https://www.ncbi.nlm.nih.gov/pubmed/27384491
http://dx.doi.org/10.18632/oncotarget.10380

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