Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells

FLT3 mutation is found in about 30% of acute myeloid leukemia (AML) patients and is associated with a poor prognosis. Several FLT3 inhibitors are undergoing investigation, while their clinical efficacies were lower than expected and several resistant mechanisms to FLT3 inhibitors have been demonstra...

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Detalles Bibliográficos
Autores principales: Chen, Fangli, Ishikawa, Yuichi, Akashi, Akimi, Naoe, Tomoki, Kiyoi, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216920/
https://www.ncbi.nlm.nih.gov/pubmed/27331411
http://dx.doi.org/10.18632/oncotarget.10147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216920/
https://www.ncbi.nlm.nih.gov/pubmed/27331411
http://dx.doi.org/10.18632/oncotarget.10147

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