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Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate

Molecular oxygen is the final electron acceptor in cellular metabolism but cancer cells often become adaptive to hypoxia, which promotes resistance to chemotherapy and radiation. The reduction of endogenous glycolytic pyruvate to lactate is known as an adaptive strategy for hypoxic cells. Whether ex...

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Detalles Bibliográficos
Autores principales: Yin, Chengqian, He, Dan, Chen, Shuyang, Tan, Xiaoling, Sang, Nianli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216956/
https://www.ncbi.nlm.nih.gov/pubmed/27374086
http://dx.doi.org/10.18632/oncotarget.10202