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Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate
Molecular oxygen is the final electron acceptor in cellular metabolism but cancer cells often become adaptive to hypoxia, which promotes resistance to chemotherapy and radiation. The reduction of endogenous glycolytic pyruvate to lactate is known as an adaptive strategy for hypoxic cells. Whether ex...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216956/ https://www.ncbi.nlm.nih.gov/pubmed/27374086 http://dx.doi.org/10.18632/oncotarget.10202 |