Cargando…
Epidermal growth factor receptor inhibitors trigger a type I interferon response in human skin
The Epidermal Growth Factor Receptor (EGFR) is centrally involved in the regulation of key processes of the epithelia, including cell proliferation, survival, differentiation, and also tumorigenesis. Humanized antibodies and small-molecule inhibitors targeting EGFR were developed to disrupt these fu...
Autores principales: | Lulli, Daniela, Carbone, Maria Luigia, Pastore, Saveria |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216978/ https://www.ncbi.nlm.nih.gov/pubmed/27322144 http://dx.doi.org/10.18632/oncotarget.10013 |
Ejemplares similares
-
The MEK Inhibitors Trametinib and Cobimetinib Induce a Type I Interferon Response in Human Keratinocytes
por: Lulli, Daniela, et al.
Publicado: (2017) -
Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity
por: Carbone, Maria Luigia, et al.
Publicado: (2018) -
Photo-Oxidation Products of Skin Surface Squalene Mediate Metabolic and Inflammatory Responses to Solar UV in Human Keratinocytes
por: Kostyuk, Vladimir, et al.
Publicado: (2012) -
Resveratrol Induces Long-Lasting IL-8 Expression and Peculiar EGFR Activation/Distribution in Human Keratinocytes: Mechanisms and Implications for Skin Administration
por: Pastore, Saveria, et al.
Publicado: (2013) -
Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21
por: Mercurio, Laura, et al.
Publicado: (2020)