Suppression of APC/C(Cdh1) has subtype specific biological effects in acute myeloid leukemia

The E3 ubiquitin ligase and tumor suppressor APC/C(Cdh1) is crucial for cell cycle progression, development and differentiation in many cell types. However, little is known about the role of Cdh1 in hematopoiesis. Here we analyzed Cdh1 expression and function in malignant hematopoiesis. We found a s...

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Detalles Bibliográficos
Autores principales: Ewerth, Daniel, Schmidts, Andrea, Hein, Manuel, Schnerch, Dominik, Kvainickas, Arunas, Greil, Christine, Duyster, Justus, Engelhardt, Monika, Wäsch, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217013/
https://www.ncbi.nlm.nih.gov/pubmed/27374082
http://dx.doi.org/10.18632/oncotarget.10196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217013/
https://www.ncbi.nlm.nih.gov/pubmed/27374082
http://dx.doi.org/10.18632/oncotarget.10196

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