Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancerassociated fibroblast accumulation

We previously demonstrated that cancer-associated fibroblasts (CAFs) accumulate at tumor sites through the interaction between a chemokine, CCL3, and its receptor, CCR5, in the late phase of colitis-associated colon carcinogenesis. Here we examined the effect of a CCR5 antagonist, maraviroc, on tumo...

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Detalles Bibliográficos
Autores principales: Tanabe, Yamato, Sasaki, Soichiro, Mukaida, Naofumi, Baba, Tomohisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217021/
https://www.ncbi.nlm.nih.gov/pubmed/27340784
http://dx.doi.org/10.18632/oncotarget.10227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217021/
https://www.ncbi.nlm.nih.gov/pubmed/27340784
http://dx.doi.org/10.18632/oncotarget.10227

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