Cargando…

Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancerassociated fibroblast accumulation

We previously demonstrated that cancer-associated fibroblasts (CAFs) accumulate at tumor sites through the interaction between a chemokine, CCL3, and its receptor, CCR5, in the late phase of colitis-associated colon carcinogenesis. Here we examined the effect of a CCR5 antagonist, maraviroc, on tumo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tanabe, Yamato, Sasaki, Soichiro, Mukaida, Naofumi, Baba, Tomohisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217021/ https://www.ncbi.nlm.nih.gov/pubmed/27340784 http://dx.doi.org/10.18632/oncotarget.10227

Ejemplares similares

Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia
por: Mukaida, Naofumi, et al.
Publicado: (2017)

Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia
por: Mukaida, Naofumi, et al.
Publicado: (2021)

Chemokines in Cancer Development and Progression and Their Potential as Targeting Molecules for Cancer Treatment
por: Mukaida, Naofumi, et al.
Publicado: (2014)

Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway
por: Baba, Tomohisa, et al.
Publicado: (2021)

Novel Process of Intrathymic Tumor-Immune Tolerance through CCR2-Mediated Recruitment of Sirpα(+) Dendritic Cells: A Murine Model
por: Baba, Tomohisa, et al.
Publicado: (2012)

Two-Faced Roles of Tumor-Associated Neutrophils in Cancer Development and Progression
por: Mukaida, Naofumi, et al.
Publicado: (2020)

Role of macrophage inflammatory protein (MIP)-1α/CCL3 in leukemogenesis
por: Baba, Tomohisa, et al.
Publicado: (2014)

Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation
por: Sasaki, So‐ichiro, et al.
Publicado: (2021)

Emergence of Cancer-Associated Fibroblasts as an Indispensable Cellular Player in Bone Metastasis Process
por: Mukaida, Naofumi, et al.
Publicado: (2020)

Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells
por: Mukaida, Naofumi, et al.
Publicado: (2018)

Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10
por: Lim, Herman D., et al.
Publicado: (2021)

Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer
por: Mukaida, Naofumi, et al.
Publicado: (2011)

Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets
por: Buskermolen, Jeroen K., et al.
Publicado: (2017)

Involvement of a Transcription factor, Nfe2, in Breast Cancer Metastasis to Bone
por: Zhang, Di, et al.
Publicado: (2020)

Blockade of chemokine-induced signalling inhibits CCR5-dependent HIV infection in vitro without blocking gp120/CCR5 interaction
por: Grainger, David J, et al.
Publicado: (2005)

Chemokine blockade
por: Wells, William A.
Publicado: (2007)

MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia
por: Baba, Tomohisa, et al.
Publicado: (2013)

Why CCR2 and CCR5 Blockade Failed and Why CCR1 Blockade Might Still Be Effective in the Treatment of Rheumatoid Arthritis
por: Lebre, Maria C., et al.
Publicado: (2011)

Chemokine (C-C Motif) Ligand 2/Chemokine Receptor 2 (CCR2) Axis Blockade to Delay Chondrocyte Hypertrophy as a Therapeutic Strategy for Osteoarthritis
por: Wang, Zidong, et al.
Publicado: (2021)

Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes
por: Connolly, Kelli A., et al.
Publicado: (2016)

Role of the Chemokine Receptors CCR1, CCR2 and CCR4 in the Pathogenesis of Experimental Dengue Infection in Mice
por: Guabiraba, Rodrigo, et al.
Publicado: (2010)

Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
por: Zhang, Hui, et al.
Publicado: (2021)

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
por: Shao, Zhehua, et al.
Publicado: (2022)

CC Chemokine Receptor (CCR)4 and the CCR10 Ligand Cutaneous T Cell–attracting Chemokine (CTACK) in Lymphocyte Trafficking to Inflamed Skin
por: Reiss, Yvonne, et al.
Publicado: (2001)

Prevention of CaCl(2)-induced aortic inflammation and subsequent aneurysm formation by the CCL3–CCR5 axis
por: Ishida, Yuko, et al.
Publicado: (2020)

The Expanding Therapeutic Perspective of CCR5 Blockade
por: Vangelista, Luca, et al.
Publicado: (2018)

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1
por: Sanchez, Julie, et al.
Publicado: (2019)

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands
por: Korbecki, Jan, et al.
Publicado: (2020)

Lack of protective effect of CCR3 blockade during experimental colitis may be related to CCR3 expression by colonic Tregs
por: Ferhat, Maroua, et al.
Publicado: (2021)

Efficient Redirection of NK Cells by Genetic Modification with Chemokine Receptors CCR4 and CCR2B
por: Feigl, Frederik Fabian, et al.
Publicado: (2023)

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4
por: Korbecki, Jan, et al.
Publicado: (2020)

Requirement for the Chemokine Receptor Ccr6 in Allergic Pulmonary Inflammation
por: Lukacs, Nicholas W., et al.
Publicado: (2001)

The expression of the chemokine receptor CCR5 in tick-borne encephalitis
por: Grygorczuk, Sambor, et al.
Publicado: (2016)

Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7
por: Jakobs, Barbara D., et al.
Publicado: (2019)

The CCR2/MCP-1 Chemokine Pathway and Lung Adenocarcinoma
por: Mittal, Payal, et al.
Publicado: (2020)

Chemokine Receptor-Targeted Therapies: Special Case for CCR8
por: Moser, Bernhard
Publicado: (2022)

Rationale of using the dual chemokine receptor CCR2/CCR5 inhibitor cenicriviroc for the treatment of COVID-19
por: Files, Daniel Clark, et al.
Publicado: (2022)

Chemokines in rheumatoid arthritis: novel, potential therapeutic targets of the CCR2 chemokine receptor signaling pathway
por: Matsushima, K, et al.
Publicado: (2003)

Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
por: Wang, Ying, et al.
Publicado: (2006)

Natural Proteolytic Processing of Hemofiltrate Cc Chemokine 1 Generates a Potent Cc Chemokine Receptor (Ccr)1 and Ccr5 Agonist with Anti-HIV Properties
por: Detheux, Michel, et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_60re8ie7d2inac7dioolb1iqmj