Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the K(ATP) channel

Gain-of-function (GOF) mutations in the pore-forming (Kir6.2) and regulatory (SUR1) subunits of K(ATP) channels have been identified as the most common cause of human neonatal diabetes mellitus. The critical effect of these mutations is confirmed in mice expressing Kir6.2-GOF mutations in pancreatic...

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Detalles Bibliográficos
Autores principales: Remedi, Maria S., Friedman, Jonathan B., Nichols, Colin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217086/
https://www.ncbi.nlm.nih.gov/pubmed/27956473
http://dx.doi.org/10.1085/jgp.201611653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217086/
https://www.ncbi.nlm.nih.gov/pubmed/27956473
http://dx.doi.org/10.1085/jgp.201611653

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