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A mechanism for acetylcholine receptor gating based on structure, coupling, phi, and flip

Nicotinic acetylcholine receptors are allosteric proteins that generate membrane currents by isomerizing (“gating”) between resting and active conformations under the influence of neurotransmitters. Here, to explore the mechanisms that link the transmitter-binding sites (TBSs) with the distant gate,...

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Detalles Bibliográficos
Autores principales: Gupta, Shaweta, Chakraborty, Srirupa, Vij, Ridhima, Auerbach, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217088/
https://www.ncbi.nlm.nih.gov/pubmed/27932572
http://dx.doi.org/10.1085/jgp.201611673