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Cigarette smoke destabilizes NLRP3 protein by promoting its ubiquitination
BACKGROUND: Cigarette smoke suppresses innate immunity, making smokers more susceptible to infection. The NLRP3 inflammasome is a multi-protein complex that releases interleukin (IL) -1β and IL -18. These cytokines are critical for a timely host response to pathogens. Whether cigarette smoke affects...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217194/ https://www.ncbi.nlm.nih.gov/pubmed/28056996 http://dx.doi.org/10.1186/s12931-016-0485-6 |