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Cigarette smoke destabilizes NLRP3 protein by promoting its ubiquitination

BACKGROUND: Cigarette smoke suppresses innate immunity, making smokers more susceptible to infection. The NLRP3 inflammasome is a multi-protein complex that releases interleukin (IL) -1β and IL -18. These cytokines are critical for a timely host response to pathogens. Whether cigarette smoke affects...

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Detalles Bibliográficos
Autores principales:	Han, SeungHye, Jerome, Jacob A., Gregory, Alyssa D., Mallampalli, Rama K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217194/ https://www.ncbi.nlm.nih.gov/pubmed/28056996 http://dx.doi.org/10.1186/s12931-016-0485-6

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