Structural prediction of the interaction of the tumor suppressor p27(KIP1) with cyclin A/CDK2 identifies a novel catalytically relevant determinant

BACKGROUND: The cyclin-dependent kinase 2 (CDK2) together with its cyclin E and A partners is a central regulator of cell growth and division. Deregulation of CDK2 activity is associated with diseases such as cancer. The analysis of substrates identified S/T-P-X-R/K/H as the CDK2 consensus sequence....

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Detalles Bibliográficos
Autores principales: Li, Jinyu, Vervoorts, Jörg, Carloni, Paolo, Rossetti, Giulia, Lüscher, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217639/
https://www.ncbi.nlm.nih.gov/pubmed/28056778
http://dx.doi.org/10.1186/s12859-016-1411-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217639/
https://www.ncbi.nlm.nih.gov/pubmed/28056778
http://dx.doi.org/10.1186/s12859-016-1411-0

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