The use of novel selectivity metrics in kinase research

BACKGROUND: Compound selectivity is an important issue when developing a new drug. In many instances, a lack of selectivity can translate to increased toxicity. Protein kinases are particularly concerned with this issue because they share high sequence and structural similarity. However, selectivity...

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Detalles Bibliográficos
Autores principales: Bosc, Nicolas, Meyer, Christophe, Bonnet, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217660/
https://www.ncbi.nlm.nih.gov/pubmed/28056771
http://dx.doi.org/10.1186/s12859-016-1413-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217660/
https://www.ncbi.nlm.nih.gov/pubmed/28056771
http://dx.doi.org/10.1186/s12859-016-1413-y

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