The Shigella Virulence Factor IcsA Relieves N-WASP Autoinhibition by Displacing the Verprolin Homology/Cofilin/Acidic (VCA) Domain

Shigella flexneri is a bacterial pathogen that invades cells of the gastrointestinal tract, causing severe dysentery. Shigella mediates intracellular motility and spreading via actin comet tail formation. This process is dependent on the surface-exposed, membrane-embedded virulence factor IcsA, whic...

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Detalles Bibliográficos
Autores principales: Mauricio, Rui P. M., Jeffries, Cy M., Svergun, Dmitri I., Deane, Janet E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217673/
https://www.ncbi.nlm.nih.gov/pubmed/27881679
http://dx.doi.org/10.1074/jbc.M116.758003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217673/
https://www.ncbi.nlm.nih.gov/pubmed/27881679
http://dx.doi.org/10.1074/jbc.M116.758003

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