Cargando…

The Shigella Virulence Factor IcsA Relieves N-WASP Autoinhibition by Displacing the Verprolin Homology/Cofilin/Acidic (VCA) Domain

Shigella flexneri is a bacterial pathogen that invades cells of the gastrointestinal tract, causing severe dysentery. Shigella mediates intracellular motility and spreading via actin comet tail formation. This process is dependent on the surface-exposed, membrane-embedded virulence factor IcsA, whic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mauricio, Rui P. M., Jeffries, Cy M., Svergun, Dmitri I., Deane, Janet E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217673/ https://www.ncbi.nlm.nih.gov/pubmed/27881679 http://dx.doi.org/10.1074/jbc.M116.758003

Ejemplares similares

Identification of Shigella flexneri IcsA Residues Affecting Interaction with N-WASP, and Evidence for IcsA-IcsA Co-Operative Interaction
por: Teh, Min Yan, et al.
Publicado: (2013)

VirF Relieves the Transcriptional Attenuation of the Virulence Gene icsA of Shigella flexneri Affecting the icsA mRNA–RnaG Complex Formation
por: Giangrossi, Mara, et al.
Publicado: (2017)

Shigella MreB promotes polar IcsA positioning for actin tail formation
por: Krokowski, Sina, et al.
Publicado: (2019)

Cysteine-Dependent Conformational Heterogeneity of Shigella flexneri Autotransporter IcsA and Implications of Its Function
por: Qin, Jilong, et al.
Publicado: (2022)

A novel antisense RNA regulates at transcriptional level the virulence gene icsA of Shigella flexneri
por: Giangrossi, Mara, et al.
Publicado: (2010)

The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function
por: Qin, Jilong, et al.
Publicado: (2020)

A multifactor regulatory circuit involving H-NS, VirF and an antisense RNA modulates transcription of the virulence gene icsA of Shigella flexneri
por: Tran, Chi Nhan, et al.
Publicado: (2011)

IcsA autotransporter passenger promotes increased fusion protein expression on the cell surface
por: Lum, Mabel, et al.
Publicado: (2012)

Polar Localization of PhoN2, a Periplasmic Virulence-Associated Factor of Shigella flexneri, Is Required for Proper IcsA Exposition at the Old Bacterial Pole
por: Scribano, Daniela, et al.
Publicado: (2014)

Activation of the Cdc42 Effector N-Wasp by the Shigella flexneri Icsa Protein Promotes Actin Nucleation by Arp2/3 Complex and Bacterial Actin-Based Motility
por: Egile, Coumaran, et al.
Publicado: (1999)

VCA nanobodies target N-WASp to reduce invadopodium formation and functioning
por: Hebbrecht, Tim, et al.
Publicado: (2017)

Interactions of WASp, myosin-I, and verprolin with Arp2/3 complex during actin patch assembly in fission yeast
por: Sirotkin, Vladimir, et al.
Publicado: (2005)

Clinicopathological significance of the microRNA‐146a/WASP‐family verprolin‐homologous protein‐2 axis in gastric cancer
por: Yao, Qunyan, et al.
Publicado: (2017)

2015 ICSA/Graybill Applied Statistics Symposium
por: Lin, Jianchang, et al.
Publicado: (2016)

2014 ICSA/KISS Joint Applied Statistics Symposium
por: Jin, Zhezhen, et al.
Publicado: (2016)

Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge
por: Karasmanis, Eva P., et al.
Publicado: (2023)

PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
por: Siddiqui, Nida, et al.
Publicado: (2019)

ICS-formoterol reliever versus ICS and short-acting β(2)-agonist reliever in asthma: a systematic review and meta-analysis
por: Hatter, Lee, et al.
Publicado: (2021)

Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint
por: Combes, Guillaume, et al.
Publicado: (2018)

Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition
por: Obaji, Ezeogo, et al.
Publicado: (2021)

SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition
por: McDonald, Nathan A., et al.
Publicado: (2023)

SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition
por: McDonald, Nathan A., et al.
Publicado: (2023)

Actin-binding Verprolin Is a Polarity Development Protein Required for the Morphogenesis and Function of the Yeast Actin Cytoskeleton
por: Vaduva, Gabriela, et al.
Publicado: (1997)

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation
por: Oser, Matthew, et al.
Publicado: (2009)

Asthma control with ICS-formoterol reliever versus maintenance ICS and SABA reliever therapy: a post hoc analysis of two randomised controlled trials
por: Hatter, Lee, et al.
Publicado: (2022)

Distributed ICSA Clustering Approach for Large Scale Protein Sequences and Cancer Diagnosis
por: K, Thenmozhi, et al.
Publicado: (2018)

Substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8
por: Ye, Yuxin, et al.
Publicado: (2020)

Consensus Bayesian assessment of protein molecular mass from solution X-ray scattering data
por: Hajizadeh, Nelly R., et al.
Publicado: (2018)

Molecular mechanisms of invadopodium formation: the role of the N-WASP–Arp2/3 complex pathway and cofilin
por: Yamaguchi, Hideki, et al.
Publicado: (2005)

TICSA TruSecure ICSA certified security associate: exam TUO-001 : training guide
por: Chapple, Mike, et al.
Publicado: (2003)

MoVrp1, a putative verprolin protein, is required for asexual development and infection in the rice blast fungus Magnaporthe oryzae
por: Huang, Lin, et al.
Publicado: (2017)

SASBDB, a repository for biological small-angle scattering data
por: Valentini, Erica, et al.
Publicado: (2014)

P119. OUTCOMES AND EXPERIENCE IN VCA - “A GLOBAL PERSPECTIVE”
por: Levin, Lawrence S., et al.
Publicado: (2022)

Dose-response relationship of ICS/fast-onset LABA as reliever therapy in asthma
por: Beasley, Richard, et al.
Publicado: (2019)

Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide
por: Hargrove, Amanda E., et al.
Publicado: (2015)

Herpes simplex virus 1 protein pUL21 alters ceramide metabolism by activating the interorganelle transport protein CERT
por: Benedyk, Tomasz H., et al.
Publicado: (2022)

Tuning Protein Autoinhibition by Domain Destabilization
por: Cho, Jae-Hyun, et al.
Publicado: (2011)

Control of mRNA decapping by autoinhibition
por: Paquette, David R, et al.
Publicado: (2018)

DCLK1 autoinhibition and activation in tumorigenesis
por: Cheng, Linna, et al.
Publicado: (2021)

Tetrameric Structures of Inorganic CBS-Pyrophosphatases from Various Bacterial Species Revealed by Small-Angle X-ray Scattering in Solution
por: Dadinova, Liubov A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qr8n6v6gfpu4vrba8j5p8r87rp