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Preference of Conjugated Bile Acids over Unconjugated Bile Acids as Substrates for OATP1B1 and OATP1B3

Bile acids, the metabolites of cholesterol, are signaling molecules that play critical role in many physiological functions. They undergo enterohepatic circulation through various transporters expressed in intestine and liver. Human organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3 cont...

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Detalles Bibliográficos
Autores principales: Suga, Takahiro, Yamaguchi, Hiroaki, Sato, Toshihiro, Maekawa, Masamitsu, Goto, Junichi, Mano, Nariyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218478/
https://www.ncbi.nlm.nih.gov/pubmed/28060902
http://dx.doi.org/10.1371/journal.pone.0169719