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Wnt Signaling Prevents the Aβ Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons

Alzheimer’s disease (AD) is a neurodegenerative disorder mainly known for synaptic impairment and neuronal cell loss, affecting memory processes. Beside these damages, mitochondria have been implicated in the pathogenesis of AD through the induction of the mitochondrial permeability transition pore...

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Detalles Bibliográficos
Autores principales: Arrázola, Macarena S., Ramos-Fernández, Eva, Cisternas, Pedro, Ordenes, Daniela, Inestrosa, Nibaldo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218554/
https://www.ncbi.nlm.nih.gov/pubmed/28060833
http://dx.doi.org/10.1371/journal.pone.0168840