DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins

The YAP and TAZ transcriptional coactivators promote oncogenic transformation. Elevated YAP/TAZ activity has been documented in human tumors. YAP and TAZ are negatively regulated by the Hippo tumor suppressor pathway. The activity and stability of several Hippo pathway components, including YAP/TAZ,...

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Detalles Bibliográficos
Autores principales: Nguyen, Hung Thanh, Kugler, Jan-Michael, Cohen, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218808/
https://www.ncbi.nlm.nih.gov/pubmed/28061504
http://dx.doi.org/10.1371/journal.pone.0169587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218808/
https://www.ncbi.nlm.nih.gov/pubmed/28061504
http://dx.doi.org/10.1371/journal.pone.0169587

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