Cargando…
Effect of a Soluble Epoxide Hydrolase Inhibitor, UC1728, on LPS-Induced Uveitis in the Rabbit
Cytochrome P450 epoxygenase isozymes convert free arachidonic acid into eicosanoids named epoxyeicosatrienoic acids (EETs) that have roles in regulating inflammation. EETs are rapidly converted to dihydroxyeicosatrienoic acids (DiHETs) by soluble epoxide hydrolase (sEH). Little is known about the po...
Autores principales: | McLellan, Gillian J., Aktas, Zeynep, Hennes-Beean, Elizabeth, Kolb, Aaron W., Larsen, Inna V., Schmitz, Emily J., Clausius, Hilary R., Yang, Jun, Hwang, Sung Hee, Morisseau, Christophe, Inceoglu, Bora, Hammock, Bruce D., Brandt, Curtis R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218821/ https://www.ncbi.nlm.nih.gov/pubmed/28066796 |
Ejemplares similares
-
Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development
por: McReynolds, Cindy B., et al.
Publicado: (2021) -
Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales
por: Kitamura, Seiya, et al.
Publicado: (2017) -
Potent Natural Soluble Epoxide Hydrolase Inhibitors from Pentadiplandra brazzeana Baillon: Synthesis, Quantification, and Measurement of Biological Activities In Vitro and In Vivo
por: Kitamura, Seiya, et al.
Publicado: (2015) -
Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty
Acid Amide Hydrolase Inhibitors
por: Kodani, Sean D., et al.
Publicado: (2018) -
Effects of Individual Circulating FFAs on Plasma and Hepatic FFA Epoxides, Diols, and Epoxide-Diol Ratios as Indices of Soluble Epoxide Hydrolase Activity
por: Oh, Young Taek, et al.
Publicado: (2023)