Systemic depletion of serum l-Cyst(e)ine with an engineered human enzyme induces production of reactive oxygen species and suppresses tumor growth in mice

Cancer cells experience higher oxidative stress from reactive oxygen species (ROS) than non-malignant cells due to genetic alterations and abnormal growth and as a result, maintenance of the anti-oxidant glutathione (GSH) is essential for their survival and proliferation(1–3). Under elevated ROS con...

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Detalles Bibliográficos
Autores principales: Cramer, Shira L., Saha, Achinto, Liu, Jinyun, Tadi, Surendar, Tiziani, Stefano, Yan, Wupeng, Triplett, Kendra, Lamb, Candice, Alters, Susan E., Rowlinson, Scott, Zhang, Yan Jessie, Keating, Michael J., Huang, Peng, DiGiovanni, John, Georgiou, George, Stone, Everett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218918/
https://www.ncbi.nlm.nih.gov/pubmed/27869804
http://dx.doi.org/10.1038/nm.4232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218918/
https://www.ncbi.nlm.nih.gov/pubmed/27869804
http://dx.doi.org/10.1038/nm.4232

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