Cargando…
Systemic depletion of serum l-Cyst(e)ine with an engineered human enzyme induces production of reactive oxygen species and suppresses tumor growth in mice
Cancer cells experience higher oxidative stress from reactive oxygen species (ROS) than non-malignant cells due to genetic alterations and abnormal growth and as a result, maintenance of the anti-oxidant glutathione (GSH) is essential for their survival and proliferation(1–3). Under elevated ROS con...
Autores principales: | Cramer, Shira L., Saha, Achinto, Liu, Jinyun, Tadi, Surendar, Tiziani, Stefano, Yan, Wupeng, Triplett, Kendra, Lamb, Candice, Alters, Susan E., Rowlinson, Scott, Zhang, Yan Jessie, Keating, Michael J., Huang, Peng, DiGiovanni, John, Georgiou, George, Stone, Everett |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218918/ https://www.ncbi.nlm.nih.gov/pubmed/27869804 http://dx.doi.org/10.1038/nm.4232 |
Ejemplares similares
-
Enzyme-mediated depletion of l-cyst(e)ine synergizes with thioredoxin reductase inhibition for suppression of pancreatic tumor growth
por: Kshattry, Sabin, et al.
Publicado: (2019) -
Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity
por: Lu, Wei-Cheng, et al.
Publicado: (2020) -
Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition
por: Saha, Achinto, et al.
Publicado: (2023) -
Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine
por: Poursaitidis, Ioannis, et al.
Publicado: (2017) -
Depletion of circulating cyst(e)ine by oral and intravenous mesna.
por: Stofer-Vogel, B., et al.
Publicado: (1993)