Cargando…

Methyl-CpG-binding domain 3 inhibits epithelial–mesenchymal transition in pancreatic cancer cells via TGF-β/Smad signalling

BACKGROUND: Methyl-CpG-binding domain 3 (MBD3) is an aberrant expression in human malignancies. However, the role of MBD3 in pancreatic cancer progression remains to be clarified. In this study, we investigated the effects of MBD3 on the epithelial–mesenchymal transition (EMT), and the underlying me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Min, He, Junbo, Li, Jie, Feng, Wen, Zhou, Hailang, Wei, Hong, Zhou, Meng, Lu, Ying, Zeng, Jian, Peng, Wanxin, Du, Fengyi, Gong, Aihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220156/ https://www.ncbi.nlm.nih.gov/pubmed/27898661 http://dx.doi.org/10.1038/bjc.2016.397

Ejemplares similares

Methyl-CpG-binding protein 2 drives the Furin/TGF-β1/Smad axis to promote epithelial–mesenchymal transition in pancreatic cancer cells
por: Wang, Huizhi, et al.
Publicado: (2020)

miR-367 promotes epithelial-to-mesenchymal transition and invasion of pancreatic ductal adenocarcinoma cells by targeting the Smad7-TGF-β signalling pathway
por: Zhu, Z, et al.
Publicado: (2015)

RBM38 is involved in TGF-β-induced epithelial-to-mesenchymal transition by stabilising zonula occludens-1 mRNA in breast cancer
por: Wu, Jing, et al.
Publicado: (2017)

MicroRNA-199b-5p attenuates TGF-β1-induced epithelial–mesenchymal transition in hepatocellular carcinoma
por: Zhou, Shao-jun, et al.
Publicado: (2017)

Fucosylated TGF-β receptors transduces a signal for epithelial–mesenchymal transition in colorectal cancer cells
por: Hirakawa, M, et al.
Publicado: (2014)

CpG-island methylation study of liver fluke-related cholangiocarcinoma
por: Sriraksa, R, et al.
Publicado: (2011)

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling
por: Yu, Y, et al.
Publicado: (2014)

Promoter CpG methylation in cancer cells contributes to the regulation of MUC4
por: Yamada, N, et al.
Publicado: (2009)

E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma
por: Araki, K, et al.
Publicado: (2011)

Disabled-2 downregulation promotes epithelial-to-mesenchymal transition
por: Martin, J C, et al.
Publicado: (2010)

NT5E CpG island methylation is a favourable breast cancer biomarker
por: Lo Nigro, C, et al.
Publicado: (2012)

No association of CpG island methylator phenotype and colorectal cancer survival: population-based study
por: Jia, Min, et al.
Publicado: (2016)

Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location
por: Bae, J M, et al.
Publicado: (2013)

Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa
por: Belshaw, N J, et al.
Publicado: (2008)

Identification of DNA hypermethylation of SOX9 in association with bladder cancer progression using CpG microarrays
por: Aleman, A, et al.
Publicado: (2008)

Hypoxia, Snail and incomplete epithelial–mesenchymal transition in breast cancer
por: Lundgren, K, et al.
Publicado: (2009)

Sox5 contributes to prostate cancer metastasis and is a master regulator of TGF-β-induced epithelial mesenchymal transition through controlling Twist1 expression
por: Hu, Jieping, et al.
Publicado: (2018)

MDM2 promotes epithelial–mesenchymal transition and metastasis of ovarian cancer SKOV3 cells
por: Chen, Ying, et al.
Publicado: (2017)

Hypermethylation of the 5′ CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis
por: Manton, K J, et al.
Publicado: (2005)

Low expression of γ-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype
por: Kawakami, K, et al.
Publicado: (2008)

Epithelial-mesenchymal transition-like events in vulvar cancer and its relation with HPV
por: Rodrigues, I S, et al.
Publicado: (2013)

Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition
por: Krubasik, D, et al.
Publicado: (2006)

Epithelial to mesenchymal transition and HPV infection in squamous cell oropharyngeal carcinomas: the papillophar study
por: Lefevre, Marine, et al.
Publicado: (2017)

Somatostatin Receptor 1, a novel EBV-associated CpG hypermethylated gene, contributes to the pathogenesis of EBV-associated gastric cancer
por: Zhao, J, et al.
Publicado: (2013)

CpG-island methylation of the ER promoter in colorectal cancer: analysis of micrometastases in lymph nodes from UICC stage I and II patients
por: Harder, J, et al.
Publicado: (2009)

Tumour-initiating capacity is independent of epithelial–mesenchymal transition status in breast cancer cell lines
por: Xie, G, et al.
Publicado: (2014)

TBLR1 is a novel prognostic marker and promotes epithelial–mesenchymal transition in cervical cancer
por: Wang, J, et al.
Publicado: (2014)

Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune-modulatory properties in cancer cells
por: Ricciardi, M, et al.
Publicado: (2015)

Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma
por: Gebauer, K, et al.
Publicado: (2013)

MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cells
por: Xu, Min, et al.
Publicado: (2016)

PRMT5 promotes epithelial‐mesenchymal transition via EGFR‐β‐catenin axis in pancreatic cancer cells
por: Ge, Lu, et al.
Publicado: (2019)

The FGFR1 inhibitor PD173074 induces mesenchymal–epithelial transition through the transcription factor AP-1
por: Nguyen, P T, et al.
Publicado: (2013)

Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial–mesenchymal transition in metastatic nasopharyngeal carcinoma
por: Horikawa, T, et al.
Publicado: (2011)

Prognostic significance of epithelial–mesenchymal transition-related markers in extrahepatic cholangiocarcinoma: comprehensive immunohistochemical study using a tissue microarray
por: Nitta, T, et al.
Publicado: (2014)

MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients
por: Pichler, M, et al.
Publicado: (2014)

miR-146a-5p mediates epithelial–mesenchymal transition of oesophageal squamous cell carcinoma via targeting Notch2
por: Wang, Cong, et al.
Publicado: (2016)

Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas
por: Colomiere, M, et al.
Publicado: (2009)

Downregulation of cell surface CA125/MUC16 induces epithelial-to-mesenchymal transition and restores EGFR signalling in NIH:OVCAR3 ovarian carcinoma cells
por: Comamala, M, et al.
Publicado: (2011)

New cellular tools reveal complex epithelial–mesenchymal interactions in hepatocarcinogenesis
por: Sagmeister, S, et al.
Publicado: (2008)

Smad7 induces hepatic metastasis in colorectal cancer
por: Halder, S K, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ekgeq22tncqokdkuna2qic1nso