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Cotargeting of CYP-19 (aromatase) and emerging, pivotal signalling pathways in metastatic breast cancer

Aromatase inhibition is one of the cornerstones of modern endocrine therapy of oestrogen receptor-positive (ER+) metastatic breast cancer (MBC). The nonsteroidal aromatase inhibitors anastrozole and letrozole, as well as the steroidal aromatase inactivator exemestane, are the preferred drugs and est...

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Detalles Bibliográficos
Autores principales: Daldorff, Stine, Mathiesen, Randi Margit Ruud, Yri, Olav Erich, Ødegård, Hilde Presterud, Geisler, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220158/
https://www.ncbi.nlm.nih.gov/pubmed/27923036
http://dx.doi.org/10.1038/bjc.2016.405