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Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils

Parkinson's disease is a debilitating neurodegenerative disorder that is pathologically characterized by intracellular inclusions comprised primarily of alpha-synuclein (αSyn) that can also be transmitted from neuron to neuron. Several lines of evidence suggest that these inclusions cause neuro...

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Detalles Bibliográficos
Autores principales: Redmann, Matthew, Wani, Willayat Y., Volpicelli-Daley, Laura, Darley-Usmar, Victor, Zhang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220183/
https://www.ncbi.nlm.nih.gov/pubmed/28068606
http://dx.doi.org/10.1016/j.redox.2016.12.032