Di2-ethylhexyl phthalate disrupts thyroid hormone homeostasis through activating the Ras/Akt/TRHr pathway and inducing hepatic enzymes

Di(2-ethylhexyl) phthalate (DEHP), as a widespread environmental pollutant and an endocrine disruptor, can disturb the homeostasis of thyroid hormones (THs). In order to elucidate roles of the MAPK and PI3K/Akt pathways and hepatic enzymes in thyroid-disrupting effects of DEHP, Sprague-Dawley rats w...

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Detalles Bibliográficos
Autores principales: Ye, Hanfeng, Ha, Mei, Yang, Min, Yue, Ping, Xie, Zhengyuan, Liu, Changjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220292/
https://www.ncbi.nlm.nih.gov/pubmed/28065941
http://dx.doi.org/10.1038/srep40153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220292/
https://www.ncbi.nlm.nih.gov/pubmed/28065941
http://dx.doi.org/10.1038/srep40153

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