Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers

Recent studies found that membrane-bound K-Ras dimers are important for biological function. However, the structure and thermodynamic stability of these complexes remained unknown because they are hard to probe by conventional approaches. Combining data from a wide range of computational and experim...

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Detalles Bibliográficos
Autores principales: Prakash, Priyanka, Sayyed-Ahmad, Abdallah, Cho, Kwang-Jin, Dolino, Drew M., Chen, Wei, Li, Hongyang, Grant, Barry J., Hancock, John F., Gorfe, Alemayehu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220301/
https://www.ncbi.nlm.nih.gov/pubmed/28067274
http://dx.doi.org/10.1038/srep40109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220301/
https://www.ncbi.nlm.nih.gov/pubmed/28067274
http://dx.doi.org/10.1038/srep40109

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