Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes

Polypurine reverse-Hoogsteen (PPRH) oligonucleotides are non-modified DNA molecules composed of two mirror-symmetrical polypurine stretches linked by a five-thymidine loop. They can fold into reverse-Hoogsteen hairpins and bind to their polypyrimidine target sequence by Watson-Crick bonds forming a...

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Detalles Bibliográficos
Autores principales: Solé, Anna, Delagoutte, Emmanuelle, Ciudad, Carlos J., Noé, Véronique, Alberti, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220335/
https://www.ncbi.nlm.nih.gov/pubmed/28067256
http://dx.doi.org/10.1038/srep39898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220335/
https://www.ncbi.nlm.nih.gov/pubmed/28067256
http://dx.doi.org/10.1038/srep39898

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