Impaired novelty acquisition and synaptic plasticity in congenital hyperammonemia caused by hepatic glutamine synthetase deficiency

Genetic defects in ammonia metabolism can produce irreversible damage of the developing CNS causing an impairment of cognitive and motor functions. We investigated alterations in behavior, synaptic plasticity and gene expression in the hippocampus and dorsal striatum of transgenic mice with systemic...

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Detalles Bibliográficos
Autores principales: Chepkova, Aisa N., Sergeeva, Olga A., Görg, Boris, Haas, Helmut L., Klöcker, Nikolaj, Häussinger, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220341/
https://www.ncbi.nlm.nih.gov/pubmed/28067279
http://dx.doi.org/10.1038/srep40190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220341/
https://www.ncbi.nlm.nih.gov/pubmed/28067279
http://dx.doi.org/10.1038/srep40190

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