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Sec16A is critical for both conventional and unconventional secretion of CFTR
CFTR is a transmembrane protein that reaches the cell surface via the conventional Golgi mediated secretion pathway. Interestingly, ER-to-Golgi blockade or ER stress induces alternative GRASP-mediated, Golgi-bypassing unconventional trafficking of wild-type CFTR and the disease-causing ΔF508-CFTR, w...
Autores principales: | Piao, He, Kim, Jiyoon, Noh, Shin Hye, Kweon, Hee-Seok, Kim, Joo Young, Lee, Min Goo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220342/ https://www.ncbi.nlm.nih.gov/pubmed/28067262 http://dx.doi.org/10.1038/srep39887 |
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