Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development

The insulin receptor substrate of 53 kDa, IRSp53, is an adaptor protein that works with activated GTPases, Cdc42 and Rac, to modulate actin dynamics and generate membrane protrusions in response to cell signaling. Adult mice that lack IRSp53 fail to regulate synaptic plasticity and exhibit hippocamp...

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Detalles Bibliográficos
Autores principales: Chou, Ai Mei, Sem, Kai Ping, Lam, Wei Jun, Ahmed, Sohail, Lim, Chin Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220365/
https://www.ncbi.nlm.nih.gov/pubmed/28067313
http://dx.doi.org/10.1038/srep40485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220365/
https://www.ncbi.nlm.nih.gov/pubmed/28067313
http://dx.doi.org/10.1038/srep40485

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