Nephroprotective Effects of N-Acetylcysteine Amide against Contrast-Induced Nephropathy through Upregulating Thioredoxin-1, Inhibiting ASK1/p38MAPK Pathway, and Suppressing Oxidative Stress and Apoptosis in Rats

Contrast-induced nephropathy (CIN) is a leading cause of hospital-acquired acute kidney injury (AKI) due to apoptosis induced in renal tubular cells. Our previous study demonstrated the novel N-acetylcysteine amide (NACA); the amide form of N-acetyl cysteine (NAC) prevented renal tubular cells from...

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Detalles Bibliográficos
Autores principales: Gong, Xuezhong, Duan, Yiru, Zheng, Junli, Wang, Yiquan, Wang, Guohua, Norgren, Svante, Hei, Tom K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220479/
https://www.ncbi.nlm.nih.gov/pubmed/28105252
http://dx.doi.org/10.1155/2016/8715185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220479/
https://www.ncbi.nlm.nih.gov/pubmed/28105252
http://dx.doi.org/10.1155/2016/8715185

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