Physiologically relevant binding affinity quantification of monoclonal antibody PF‐00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation

BACKGROUND AND PURPOSE: A monoclonal antibody (PF‐00547659) against mucosal addressin cell adhesion molecule (MAdCAM), expressed as both soluble (sMAdCAM) and trans‐membrane (mMAdCAM) target forms, showed over 30‐fold difference in antibody‐target K(D) between in vitro (Biacore) and clinically deriv...

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Detalles Bibliográficos
Autores principales: Wang, Mengmeng, Kussrow, Amanda K, Ocana, Mireia Fernandez, Chabot, Jeffrey R, Lepsy, Christopher S, Bornhop, Darryl J, O'Hara, Denise M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221447/
https://www.ncbi.nlm.nih.gov/pubmed/27760281
http://dx.doi.org/10.1111/bph.13654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221447/
https://www.ncbi.nlm.nih.gov/pubmed/27760281
http://dx.doi.org/10.1111/bph.13654

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